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Contraindicated (one)pentobarbital will lessen the level or influence of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females must not pick estradiol valerate/dienogest as their contraceptive while making use of potent CYP3A4 inducers because of potential lessen in contraceptive efficacy.